Abstract OpenTox Asia 2019
Network Pharmacology Approaches for the Design and Development of Potent Drugs for Hyperglycaemia
Recent progress in the area of system biology, pharmacology, bioinformatics, network biology, and computational sciences brings the concept of network pharmacology. This concept, essentially based on the application of multiomics and systemic biological, was developed by Hopkins [1]. Network pharmacology approaches are extensively used for understanding the mechanisms of action of various drugs and their side effects. These approaches have also been utilized to predict the relation between drugs and diseases and also to predict the potential targets [2-4]. Hyperglycaemia is a serious life threatening condition where blood glucose level increases substantially. Hyperglycaemia generally diagnosed in patients with diabetes mellitus. There may be other sources for hyperglycaemia like pancreatic cancer, pancreatitis, cushing’s syndrome, certain types of tumors, low level of vitamin B-12 or vitamin-D and a few medications etc. This situation is currently treated by metformin, alpha-glucosidase inhibitors, sulfonylureas, thiazolidinedione etc drugs. However, long term uses of these drugs are associated with many complications like catabolism, chronic kidney diseases, cardiovascular problems etc. We plan to utilize network pharmacology approaches for designing effective and less toxic alternatives for the treatment of hyperglycaemia. This includes the collection of all the available herbal drugs for understanding the relation and finding the binding patterns.
-
Hopkins, AL. Nat. Biotech. 2007; 25:1110-1111.
-
Wei S, Niu M, Wang J, Wang J, Su H, Luo S, Zhang X, Guo Y, Liu L, Liu F, Zhao Q, Chen H, Xiao X, et al. Drug Des Devel Ther. 2016; 10:733–43.
-
Li X, Wu L, Liu W, Jin Y, Chen Q, Wang L, Fan X, Li Z, Cheng Y. PLoS One. 2014; 9:e95004.
-
Lee JH, Zhao XM, Yoon I, Lee JY, Kwon NH, Wang YY, Lee KM, Lee MJ, Kim J, Moon HG, In Y, Hao JK, Park KM, et al. Cell Discov. 2016; 2:16025.