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Gaurav Aggarwal
OpenTox 2020 Intern

I am a final year postgraduate student pursuing M.Sc Life Science (Bioinformatics) at the Central University of Punjab where I have learned many subjects which deal with the various aspects of genomics and proteomics. I did my B.Sc(H) in Biomedical science from the University of Delhi where I learned many concepts related to interdisciplinary science. I have always wanted to explore the field of computational power to decipher various interactions of biomolecules.

I was a member of Think lab where I did my project entitled “Genetics of C.elegans and Chemotaxis plasticity in nematodes” at the University of Delhi which was presented at Tata Institute of Fundamental Research. I did my Internship project in CSIR-IGIB where I published an Award-winning paper as a first author in the 6th world congress on nanomedical Science, International Society for Nanomedical Sciences entitled “Synthesis of silver nanoparticles using Terminalia bellerica: Physicochemical characterization and their antibiofilm evaluation”. I recently completed a project internship at CSIR-NEIST, the project work entitled “Polyherbal formulation of Muscular dystrophy”. My recent project work in Young Science Leadership (YSL) under the Science Leadership community is ongoing which is entitled “System biology approach in discovery and development of personalized medicine through in silico approach”. 

I want to create a drug discovery and development database which will contain the Physicochemical properties of drug-target interactions in every possible orientation to provide the biotech and pharmaceutics field an add-on to their time-consuming research.

Toxicology Resources - OpenTox Session

COVID-19 Literature mining, Collection of Information on repurposed drugs and Toxicological software

The causative agent of the COVID-19 pandemic was identified as the SARS-CoV-2 virus, which has already infected over 114 million people with the death of more than 2.5 million people across the globe. This virus has been identified to be a single-stranded, positive-sense RNA virus that belongs to the Coronaviridae family. There was a need to make a collection of available literature on COVID-19 related repurposed drugs through literature mining and through identifying different and reliable available resources on approved and established drugs. Here we discuss repurposed drugs that are already drugs with their ATC class, mechanisms of action, known CYP interactions and toxicity, etc. We also collected data on toxicological software that are open source and freely available toxicity prediction software with high accuracy. We sorted the data accordingly so the user can find their specific need from the collection on the OpenTox website.