A Global Meeting for a Safer World 20 - 24 September 2021
Times in CEST - follow the links below to view full session descriptions & abstracts
20 September 2021
- 13:00-13:05 Chair: Sandra Coecke (European Commission Joint Research Centre)
- 13:05-13:25 Talk: Surat Partvatam (Centre for Cellular & Molecular Biology, India) & Sham Bharadwaj(Centre for Cellular & Molecular Biology, India), Research complex models by global scientific collaborations and practical workshops on good practices
- 13:25-13:45 Talk: Ivana Campia (European Commission Joint Research Centre) & Sofi Batista Leite (European Commission Joint Research Centre), Models and Methods in Biomedical Research: the reporting bottlenecks to overcome
- 13:45-14:05 Talk: Sonja Beken (The Federal Agency for Medicines and Health Products) & Sandra Coecke (European Commission Joint Research Centre), Models and Methods: the reality check by the regulatory science community in a world of change
- 14:05:14:30 Discussion
15.00 - Session 2. Advances in Cheminformatics Analysis and Prediction of Chemical Mixtures
- 15:00-15:05 Chair: Vinicius Alves (UNC)
- 15:05-15:25 Talk: Kunal Roy (Jadavpur University), Predictions of toxicity of polar and nonpolar narcotic chemical mixtures using QSAR
- 15:25-15:45 Talk: Travis Maxfield (Duke University), The N-ary in the Coal Mine: Preventing Mixture Model Failure with Proper Validation
- 15:45-16:05 Talk: Eugene Muratov (The University of North Carolina), Viribus unitis – utility and modeling of drug combinations
- 16:05-16:50 Discussion and Poster Presentation: Joyita Roy (Jadavpur University), Nano-QSTR modeling of metal oxide nanoparticles (MeOxNPs) & Mainak Chatterjee (Jadavpur University), Development and Application of a New Similarity-Based Read-Across Algorithm for the Prediction of Nanotoxicity of small datasets
17.00 - Session 3. Complex in Vitro Models
- 17:00-17:05 Chair: Kasper Renggli (PMI)
- 17:05-17:25 Talk: Andy Forreryd (SenzaGen), A novel in vitro approach for quantitative assessment of skin sensitizing potency
- 17:25-17:45 Talk: Adrián García-Salvador (GAIKER), In vitro toxicological assessment of representative aerosolized cerium oxide and silver nanoparticles and commercial microparticles
- 17:45-18:05 Talk: Jonne Rietdijk (Uppsala University), Exploring combination effects of chemicals by untargeted morphological profiling
- 18:05-18:50 Discussion and Poster Presentation: Montse Mitjans (University of Barcelona), Identification of photo allergens by cellular assays in vitro
21 September 2021
13.00 - Session 4. Genotoxicity Modelling and Testing
- 13:00-13:05 Chair: Paula Braun (PETA)
- 13:05-13:25 Talk: Federica Madia (European Commission Joint Research Centre), EURL ECVAM Genotoxicity and Carcinogenicity Database of Substances Eliciting Positive and Negative Results in the Ames Test
- 13:25-13:45 Talk: Robert Foster (Lhasa Limited), In Silico Prediction of Genotoxicity: Current Applications and Future Perspectives
- 13:45-14:05 Talk: Sebastian Hoffmann (SEH consulting and services), Validation of the reconstructed human skin micronucleus (RSMN) assay to follow-up positive results from standard in vitro genotoxicity assays
- 14:05-14:30 Discussion
15.00 - Session 5. Model-Based Approaches to Increase Predictability in Early Drug Development
- 15:00-15:05 Chair: Thierry Lave (Roche)
- 15:05-15:35 :Talk: Ken Wang (Roche), On the journey towards individualized risk-benefit prediction: cardiac safety assessment as a case study showing the potential of an integrative approach
- 15:35-16:05: Talk: Guy Meno Tetang (Astrazeneca), Using a Quantitative System Pharmacology (QSP) platform to predict the efficacy and safety of AAV-mediated Protein Delivery
- 16:05-16:35 Discussion and Poster Presentation: Manjari Singh (Assam University), Recent advancement in developing prolyl hydroxylase-2 activators for breast cancer chemoprevention: A Bio-molecular in silico study
- 17:00-17:05 Chair: Hanan Osman-Ponchet (PKDERM)
- 17:05-17:25 Talk: Isabelle Sartori Tamburlin (Pierre Fabre Laboratories), Determination of safe recommended doses for essential oils consumed as food supplements
- 17:25-17:45 Talk: Manon Barthe (PKDERM), Comparison of the expression of SARS-CoV-2 receptors in in vitro skin and lung models
- 17:45-18:05 Talk: Karina Cuanalo-Contreras (SABEU GmbH), In vitro models of cellular barriers for safety assessment in drug development
- 18:05-18:30 Discussion
19.00 - Session 7. Use of omics derived evidence supporting risk assessment
- 19:00-19:05 Chair: Pranika Singh (Edelweiss Connect)
- 19:05-19:25 Talk: Thomas Darde (SciLicium), Applications of Omics analysis in supporting Toxicology and Safety Assessment Investigation
- 19:25-19:45 Talk: Giulia Callegaro (Leiden University), The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment
- 19:45-20:05 Talk: Anja Wilmes (VU Amsterdam), Application of TempO-Seq transcriptomics to study temporal effects of cadmium chloride in human iPSC-derived renal proximal tubular cells
- 20:05-20:50 Discussion and Poster Presentation: Indusha Kugathas (Univ Rennes), The TOXsIgN database: A one-stop web resource for sharing and comparing toxicogenomic signatures
22 September 2021
11:00-13:00 Workshop on COVID-19 data analysis and modeling
- Data curation
- Adverse events and drug repurposing
- Vaccine adverse events data
- Modeling applications
13.00 - Session 8. Predictive Toxicology supporting Assessment
- 13:00-13:05 Chair: Asish Mohapatra (Health Canada)
- 13:05-13:25 Talk: Olga Tcheremenskaia (Istituto Superiore di Sanità, Rome), QSAR models: improving prediction confidence and expanding regulatory acceptance, First report on OECD (Q)SAR Assessment Framework Project
- 13:25-13:45 Talk: Jitao David Zhang (Roche) and Manuela Jaklin (Roche and University of Konstanz; currently Weleda AG), Optimization of the TeraTox assay for preclinical teratogenicity assessment
- 13:45-14:05 Talk: Ishita Virmani (Masaryk University), An in vitro test battery for organochlorine mixture toxicity assessment on the male reproductive system
- 14:05-14:25 Talk: Katie O'Rourke (Dublin University), The acute, chronic and transgenerational effects of antibiotics on Daphnia Magna
- 14:25-14:50 Discussion and Poster Presentation: Anna Michalaki (Dublin University), Toxicity responses of daphnids exposed to butyl methyl imidazolium ionic liquids & Allan McGivern (Dublin University), The impact of a complex mixture of pollutants on key enzymes in Daphnia Magna
15.00 - Session 9. Endocrine Disruption: In vitro testing and in silico modeling
- 15:00-15:05 Chair: Paul Thomas (KREATiS)
- 15:05-15:25 Talk: Peter A. Behnisch (BDS), Development and application of a comprehensive validated endocrine disrupter panel using human mechanistic assays
- 15:25-15:45 Talk: Costanza Rovida (CAAT), Challenges in implementing NAMs (New Approach Methodologies) for Endocrine Disruption characterization of chemicals in the regulatory context
- 15:45-16:05 Talk: Gregory Lemkine (WATCHFROG), Medaka eggs tests, a screening tool to evaluate the endocrine activity of new ingredients?
- 16:05- 16:25 Talk: Zlatomir Todorov (KREATiS), SESAME-3D: framework for modeling protein-ligand interactions for detection of endocrine disruptor potential of chemicals
- 16:25-17.00 Discussion and Poster Presentation: Anish Gomatam (Bombay College of Pharmacy), Predicting Endocrine Disruption and Potential CNS Toxicity using the EVANS QSPR methodology
23 September 2021
13.00 - Session 10. Environmental Risk Assessment of Personal Care Products
- 13:00-13:05 Chair: Ramez Labib (Avon)
- 13:05-13:25 Talk: Jennifer Saxe (EcoSafety and Sustainability Inc), Using Multiple Assessment Methods in a Customized Approach to Support Eco-Innovation for Personal Care Products
- 13:25-13:45 Talk: Chris Bartlett (Equilibrium Consulting), An Approach to Data Mining Environmental Data for Personal Care Products
- 13:45-14:05 Talk: Lisa Hoffman (Avon), Evaluating the Biodegradability of Cosmetics and Personal Care Products
- 14:05-14:30 Discussion
15.00 - Session 11. Computational Approaches in Predicting Toxicity Endpoints
- 15:00-15:05 Chair: Roustem Saiakhov (MultiCase)
- 15:05-15:25 Talk: Stefan Pudenz (Covance Labs), QSAR of Metabolites on the Basis of Data-Driven if-then-rules
- 15:25-15:45 Talk: Roustem Saiakhov (MultiCase), QSAR Assessments of Human Adverse Effects
- 15:45-16:05 Talk: Alejandra Trejo-Martin (Gilead Sciences), QSAR Approaches for Potential Mutagenic Impurities Assessment
- 16:05-16:25 Talk: Anke Wilm (University of Hamburg), Biologically meaningful descriptors for the prediction of skin sensitization potential of small molecules
- 16:25-16:50 Discussion and Poster Presentation: Kiril Lanevskij (Aukštieji Algoritmai), Using a combination of quantitative and censored data for QSAR modeling of hERG inhibitory constants
- 17:00-17:05 Chair: Arantza Muriana (Biobide)
- 17:05-17:25 Talk: Kristen Ryan (NIH), National Toxicology Program’s approach to refine and harmonize zebrafish screening protocols for chemical safety assessment
- 17:25-17:45 Talk: Stefan Scholz (Helmholtz Centre for Environmental Research), Grouping of chemicals and prediction of hazards using automated phenotype assessment in zebrafish embryos
- 17:45-18:05 Talk: Arantza Muriana (Biobide), Harmonization, and Validation of zebrafish Light-dark transition test to predict Developmental Neurotoxicity for the OECD test guidelines for DNT (TG 426 and 443)
- 18:05-18:30 Discussion
24 September 2021
11.00 - Session 13. Sustainable ecosystem for in silico models
- 11:00-11:00 Chair: Hyun-Kil Shin (KIT)
- 11:05-11:25 Talk: Emilio Benfenati (Mario Negri Institute) The use of in silico models and read-across for ecosystems. Integrating multiple perspectives
- 11:25-11:45 Talk: Egon Willighagen (Maastricht University) Sustainable Predictive Toxicology with Open Science approaches
- 11:45-12:05 Talk: Tomoko Aoyagi (OECD), Updates on OECD QSAR Toolbox and its application
- 12:05-12:50 Discussion and Poster Presentation: Denis Habauzit (ANSES), Used combined in silico approaches for the prioritization of mycotoxin toxicity assessment
13.00 - Session 14. Data Management and Sharing
- 13:00-13:05 Chair: Ugis Sarkans (EMBL - EBI), Hinxton)
- 13:05-13:25 Talk: Tomaz Mohoric (Edelweiss Connect GmbH), An approach to the reproducible analysis of toxicological data
- 13:25-13:45 Talk: Danyel Jennen (Maastricht University), FAIR data management in toxicogenomics: the good, the bad, the ugly
- 13:45 -14:05 Talk: Allan Peter Davis (North Carolina State University), Leveraging CTD data to fill in knowledge gaps for environmental health
- 14:05- 14:25 Talk: Thomas Luechtefeld (Insilica), Data Interoperability Inspired By Open Source
- 14:25-14:50 Discussion and Poster Presentation: Jamie Moose (ASRC Federal), National Toxicology Program Histopathology and Clinical Pathology Dictionary
15.00 - Session 15. Semantic Interoperability in Data Annotation and Migration
- 15:00-15:05 Chair: Michelle Angrish (US EPA)
- 15:05-15:25 Talk: Jennifer Olker (U.S. Environmental Protection Agency), Enhancing the Interoperability of the Ecotoxicology (ECOTOX) Knowledgebase via Mapping to Existing Vocabularies and Ontologies
- 15:25-15:45 Talk: Marc Teunis (HU - University of Applied Science), Building adverse outcome pathways with natural language processing
- 15:45-16:05 Talk: Brian Howard (Sciome), Towards Automating Information Extraction with FIDDLE: From Text Annotation to Interoperable Information Extraction via Machine Learning
- 16:05-16:50 Discussion and Poster Presentation: Linda Elberskirch (Leibniz Institute for New Materials), Description Standards and Quality Criteria for Data Re-Use in Nanosafety Research
