All Times in CET (e.g.13.30 CET = 7.30 am New York, 12.30 pm London, 5 pm Mumbai, 10.30 pm Tokyo)
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Program
Monday 1 December
Keynote Talks
13:00 CET From Roadmaps to Regulation: OECD’s Role in Advancing NAMs for Global Chemical Safety, Magdalini Sachana (OECD)
13:45 CET Current hazard identification practice and NAM research: Never the twain shall meet? , Michael Dourson (TERA)
14:30 CET EC roadmap towards phasing out of animal testing in chemical safety assessment & change management, Elisabet Berggren (EC JRC)
Session 1. Data Science and Informatics
15:30 CET Beyond Biology as Usual: How In Silico and Cell-Based Platforms Are Rewriting Preclinical Research, Kasper Renggli (University of Applied Science Northwestern Switzerland)
16:00 CET Mechanistic Exploration of Parkinson’s Disease by Integrating Co-expression Networks with AOPs, Yordan Yordanov (Medical University of Sofia)
16:30 CET Smarter Toxicology Ahead: The Role of AI in Shaping Adverse Outcome Pathways (AOPs), Clemens Wittwehr (EC JRC)
17:00 CET Title TBA, Arantza Muriana (Biobide)
17:30 CET FL-CHEMSAFE: Advancing Safety Assessment of Chemicals Through Federated Learning, Nicoletta Spinu (ai4cosmetics)
18:00 CET TOXIN KG: supporting animal-free risk assessment of cosmetics, Sara Sepehri (VUB)
18:45-20:00 CET Hands-on Training: Application of Safe and Sustainable by Design Methodology and Tools to Product Design and Innovation; Module 1. The training will be led by Barry Hardy, Ghada Tagorti, Connor Hardy, and Asmaa Ali (Edelweiss Connect)
In this training session we will introduce the use of tools and databases supporting the application of safe and sustainable by design (SSbD) methodology and tools to product design and innovation. Supporting the training exercises, participants will be provided access to tools and knowledge resources used to support the activities made openly and freely available on the Internet. Each day will focus on a particular sub-topic and tool(s).
1a. Introduction to SSbD concepts and methods
1b. SSbD workflow and resource support
Tuesday 2 December
Keynote Talks
13:00 CET Better Modelling Improves Non-Animal Chemical Safety Assessment, Mark Cronin (Liverpool John Moores University)
14:00 CET Exposome-scale Exposure Reconstruction, John Wambaugh (UL)
Session 2. Computational Toxicology
15:15 CET Lessons from the Tox24 Challenge: Modern AI/ML contribute models with highest accuracy but we still need a better interpretation of them, Igor Tetko (TUM)
15:45 CET Next Generation Predictive Toxicology with Cell Painting, Stefan Kramer (Johannes Gutenberg University Mainz)
16:15 CET Cyclodextrins as Protective Hosts for Chemical UV Filters, Grigorios Megariotis (NTUA)
16:45 CET Empowering Predictive Toxicology with Phenomics and Automation, Ola Spjuth (University of Uppsala)
17:15 CET Integrative Approaches in Species Sensitivity Distribution Modeling Cross Species Modelling, Ghada Tagorti (OpenTox)
17:45 CET Transparent and computer-assisted integration of NAM results in decision-making considering uncertainty, Karolina Kopanska (Johns Hopkins University)
18:30-19:30 CET Hands-on Training: Application of Safe and Sustainable by Design Methodology and Tools to Product Design and Innovation; Module 2
2. Using AI-assisted resources to find and extract knowledge from:
a) Safety Data Sheets
b) Public Knowledge Sources
c) Literature
d) Regulatory Toxicology Data
19:30-21:00 CET Poster Session and Networking (Poster Presentations and Chat set in a Virtual World)
Wednesday 3 December
Keynote Talk
Session 3. AI Assistance to Scientific Research
14:00 CET The OpenTox AI Framework, Barry Hardy (OpenTox)
14:30 CET Frameworks for using Large Language Models in Toxicological Risk Assessment, Glenn Myatt (Informence Labs)
15:00 CET O-QT: Automating OECD QSAR Toolbox Workflows for Predictive Toxicology and Risk Assessment with LLM Agents, Ivo Djidrovski (Utrecht University)
15:30 CET The Persistent Agent: Orchestrating AI, Knowledge Graphs, and Predictive Toxicology for a Safer World,Thomas Luechtefeld (in silica)
16:00 CET Artificial Intelligence in Predictive Toxicology – Approaches and Prerequisites, Andreas Bender (University of Cambridge)
16:30 CET AOPGraphExplorer 2.0: An Integrated Graph-Based Platform for Multi-Domain Annotation and Visualization of Adverse Outcome Pathways, Asmaa Ali (Edelweiss Connect)
17:30-18:30 CET Hands-on Training: Application of Safe and Sustainable by Design Methodology and Tools to Product Design and Innovation; Module 3
3. Using software tools for SSbD
a) Introduction
b) Preparation of a Formulation
c) Hazard Profiling and Scoring of a Formulation and Ingredients
d) Considering function, hazard evidence and scoring for ingredient substitutions
e) Evaluation of SSbD occupational scoring
f) Consumer risk assessment
g) Sustainability and Environmental Assessment
h) Life Cycle Impact Factors
i) Social and Economic Analysis
18:30-20:00 CET Poster Session and Networking (Poster Presentations and Chat set in a Virtual World)
Thursday 4 December
Keynote Talk
13:00 CET Nephrotoxicity testing in vitro — what we know and what we need to know. A tribute to Prof. Dr. Walter Pfaller (1945 to 2025), Paul Jennings (Free University of Amsterdam)
Session 4. Biological Advances in Toxicology
14:00 CET Development and applications of blood-brain barrier in vitro models for neurotoxicity assessment, Winfried Neuhais (Austrian Institute of Technology)
14:30 CET Towards Digital Drug Development with a Trifecta of Multi-Organ Chips, Robotics and AI, Florian König-Huber (TissUse)
15:00 CET Stem cell derived BBB like cells - How likeable are they?, Maxime Culot (University of Artois)
15:30 CET How Data and Models for Mechanistic Toxicology can guide Biological Experiments, Jeff Wiseman (Edelweiss Connect)
16:00 CET An Integrated Approach to Testing and Assessment for Developmental Neurotoxicity: Fluoxetine as a Case Study, Sue Marty (Dow Chemical)
16:30 CET Transversal Learning in Regulatory application of Complex Mechanistic models in Risk Assessment. Thyroid Disruptors and what we learn from Drug Development, Stephan Schaller (EsqLabs)
17:30-19:00 CET Hands-on Training: Application of Safe and Sustainable by Design Methodology and Tools to Product Design and Innovation; Module 4
4a. Including Evidence from New Approach Test Methods
4b. Including Physical Chemical Characterisation Evidence
5. Using Workflow Software for documenting all SSbD Steps and Decisions
19:00-20:30 CET Poster Session and Networking (Poster Presentations and Chat set in a Virtual World)
Friday 5 December
Keynote Talks
13:00 CET Ensuring Reproducibility of Quantitative Multiomics Data for Regulatory Decision-Making, Leming Shi (Fudan University & International Human Phenome Institutes)
14:00 CET Title TBA, Speaker TBA
Session 5. Regulatory Acceptance and Use of NAMs
15:00 CET Beyond QSARs – Quantitative Knowledge-Activity Relationships (QKARs) for Toxicity Prediction, Li Dongying (US FDA)
15:30 CET NAMs for regulatory use in food safety: Challenges and opportunities, George Kass
16:00 CET Regulatory Acceptance and Use of Large Language Models in Toxicological Risk Assessment, Arianna Bassan (Innovatune)
16:30 CET Progress and difficulty in gaining regulatory acceptance of PBPK modeling and mechanism of toxicity in risk assessments., Harvey Clewell (Ramboll)
17:00 CET From Innovation to Implementation: Driving Acceptance of 3Rs-Aligned Technologies, Megan R. LaFollette (The 3Rs Collaborative)
16:00-17:00 CET Closing Panel Discussion - Quo Vadis OpenTox?
17:00-19:00 CET Final Social and Network Event (To be held in the Poster Presentation Room set in a Virtual World)