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OpenTox Euro 2018

OpenTox Euro 2018 Program

Conference Theme: Bridging the gap between experimental and computational work in safety and risk assessment

Venue: Titania Hotel, Athens, Greece

Dates: October 9-11, 2018 

Organising Committee: Barry Hardy (Douglas Connect), Thomas Exner (Douglas Connect), Iseult Lynch ( University of Birmingham), Philip Doganis (NTUA), Thomas Carney (University of Birmingham), Haralambos Sarimveis (NTUA)

Tuesday, 9 October 

 15.30

 

Pre-Conference Hackathon with NanoCommons (link to more information)

Wednesday, 10 October 

 

S1.

Session 1: Experimental and Computational Toxicological Evaluation of Engineered Nanomaterials, Session Chairs: Costas Charitidis (NTUA) and Vladimir Lobaskin (UCD)

9.00

 

Chair's Introduction 

9.10

 

Health and Safety Issues in the development of (nano) carbon-based materials and composites, Kyriaki Kyriakidou (NTUA)

9.40

 

Effect of nanostructured titanium dioxide on photoinduced cancer treatment, Nefeli Lagopati (NTUA)

10.10

 

Multiscale modelling of nanoparticle-membrane interaction, Nick Quirke (Imperial college, UK)

10.40

 

Coffee Break 

 

S2.

Session 2: Industrial Applications in Safety Assessment, Session Chair: Barry Hardy (Douglas Connect)

11.00

 

Chair Introduction 

11.05

 

New Developments in Toxicogenomics Applications, Roland Grafstrom (Karolinska Institute)

11.35

 

Predictive Modelling of Adverse Outcomes, Ola Spjuth (Genetta Soft)

12.05

 

Enalos+ KNIME Nodes for cheminformatics and nanoinformatics applications with the aid of GPU acceleration, Antreas Afantitis (NovaMechanics Ltd)

12.35

 

Collaboration in Integrated Testing and Assessment, Barry Hardy (Douglas Connect)

13.00 

 

Lunch 

 

 S3.

Session 3: Hands-on Workshop on Biokinetics Modelling, Led by Haralambos Sarimveis and Philip Doganis (NTUA)

14.00

 

Aim: understanding the use, form, inputs and outputs of physiologically based (PBPK) pharmacokinetic models. Presentation of software applications for developing PBPK models. Customising PBPK to individual time-drug concentration data. Creating optimal drug dosage regimens

16.00

 

Knowledge Café

17.00 

 

End of Workday 

19.00

 

Dinner in Athens after leaving Titania Hotel 

Thursday, 11 October 

 

S4. 

Session 4: Organ-on-a-chip: combining the in-vitro and in-vivo approaches, Session Chair: Andrew Nelson (University of Leeds, UK)

9.00

 

Chair Introduction  

9.05

 

Chip-based platform: An in vitro for toxicity screening, Yvonne Kohl, (Fraunhofer IBMT)

9.30

 

Third Generation Rapid High Throughput Screening Platform for Pharma, Toxicants, and Nanomaterials, Andrew Nelson, (University of Leeds, UK)

9.55   3D Models and Organs on Chip, Espen Mariussen (Norwegian Institute for Air Research (NILU) 

10.30

 

Coffee Break 

 

S5.

Session 5: In-silico approaches for risk assessment from a regulatory perspective, Session Chair: Andrea Haase (BfR)

11.00

 

Chair Introduction 

11.05

 

On the regulatory use of in silico methods under REACH and CLP, Matthias Herzler (BfR)

11.35

 

PBPK based approach towards risk assessment, Barbara Wisniowska (Jagiellonian University)

12.05

 

Towards Nanomaterial Grouping, Andrea Haase (BfR) 

12.30

 

Evaluation of the applicability of existing QSAR models and Read Across strategies for predicting the genotoxicity of pesticides and their metabolites, Olga Tcheremenskaia (Istituto Superiore di Sanità)

13.00

 

Lunch 

14.00

S6.

Session 6: Hands-on Workshop - Building risk assessment workflows with OpenRiskNet, led by Philip Doganis (NTUA) and Thomas Exner (Douglas Connect)

16.00

 

End of OpenTox Euro 2018 conference