OpenTox 2023 Virtual Conference - Preliminary Program
All Times in CET (e.g.13.30 CET = 7.30 am New York, 12.30 pm London, 5 pm Mumbai, 10.30 pm Tokyo)
6 November 2023
13-15 CET Session 1 - OpenToxAI - Open AI-enabled Predictive Toxicology and Next Generation Risk Assessment, Session Chair: Barry Hardy (Edelweiss Connect)
- OpenToxAI - A Perspective and Open Framework for Application of AI in Toxicology and Risk Assessment, Barry Hardy (Edelweiss Connect)
- Building Large Scale Chemical Property Data With BioBricks-ai, Thomas Luechtefeld (Insilica)
- A Knowledge Graph For Chemical Safety, Zakariyya Mughal (Insilica)
15-17 CET Session 2 - Leveraging In Silico Approaches for Advancing Adverse Outcome Pathways in Risk Assessment, Session Chair: Marvin Martens (University of Maastricht)
- Adverse Outcome Pathways – Putting Regulatory Action in the High Seat or in Pandora’s Box? Marcin Wlodzimierz Wojewodzic (Cancer Registry of Norway and the Norwegian Institute of Public Health)
- Development of a gene expression-based quantitative AOP for nephrotoxicity, Filippo di Tilio (Leiden University)
- Nano-NAMS DB – showcase of the first database dedicated to nano-specific alternative methods in human hazard and safety assessment under different EU regulations, Maciej Gromelski (QSAR Lab)
17-19 CET Session 3 - Endocrine Activity Predictive Models, Session Chair: Jie Liu (FDA NCTR)
- Collaborative Computational Projects for Virtual Screening of Endocrine Disrupting Chemicals, Kamel Mansouri (NIEHS)
- Machine Learning-assisted Screening and Toxic Studies of New Pollutants, Shulin Zhuang (Zhejiang University)
- Development Predictive Models and Tool for Screening Potential Endocrine-Disruptors, Guoxiu Shan (Nanjing University of Science and Technology)
7 November 2023
13-15 CET Session 4 - Metabolism Studies in Mechanistic Toxicology, Session Chair: Patrik Lundquist (Uppsala University)
- Strategies for metabolite identification, Pawel Baranczewski (Uppsala University)
- Modeling human hepatic metabolism and toxicity using NAMs: How much is enough?, Stephen S Ferguson (NIEHS)
- Use of advanced hepatic 3D cultures and microphysiological systems in in vitro studies of hepatic metabolism, Volker Lauschke (Karolinska institute)
15-17 CET - OpenTox Intern and Hackathon Session
- Collection of Toxicology software to support user access and utilisation, Akyianu Gyamfi (OpenTox)
- Prediction of Molecular Initiating Event Inceptive Stage in Adverse Outcome Pathway Using Large Language Model, Ghada Tagorti (OpenTox)
17-19 CET Session 5 - Advanced in vitro models for toxicity testing, Session Chair: Anja Wilmes (Vrije Universiteit Amsterdam)
- Application of organ on a chip models for toxicity studies, Beren Atac (TissUse)
- In vitro models to address innate immunity and inflammatory responses, Doris Wilflingseder (Medical University of Innsbruck)
- Application of iPSC-derived renal proximal tubular cells for toxicity testing, Tamara Meijer (Vrije Universiteit Amsterdam)
- Stem cell-derived in vitro models of the Blood brain barrier: Challenges and Opportunities, Maxime Culot (University of Artois)
8 November 2023
13-15 CET Session 6 - FAIR Data and Models, Session Chair: Priyanka Banerjee (Charité)
- Toxicology data: harmonization, sharing and publishing, Ugis Sarkans (EBI)
- Omics Data Analysis Framework, Florian Caiment (University of Maastricht)
15-17 CET Session 7
Collaborative Workshop Session on OpenToxAI - A Perspective and Open Framework for Application of AI in Toxicology and Risk Assessment, as presented by Barry Hardy (Edelweiss Connect) in Session 1 on 6 November. This session will be an opportunity for the group to discuss principles and issues raised by the draft perspective manifesto and article, and to also contribute with attribution to comments and suggested edits directly into the draft article document.
17-19 CET Session 8 - Practical Applications in Explainable AI supporting Predictive Toxicology, Session Chair: Swapnil Chavan (RISE)
- Explainable Artificial Intelligence for Structure-Activity Relationships in Real-World Drug Design Datasets, Tobbias Harren (University of Hamburg)
- Unlocking the Black Box: A Practical Session on Explainable AI with Gradient Boosting Approaches, Pablo Rodriguez (Pompeu Fabra University)
9 November 2023
13-15 CET Session 9 - Organ on a Chip Innovation in Safer Design, Session Chair: Kasper Renggli (PMI)
- Inhalation toxicology opportunities using the Vitrocell Cloud system and the smoking machine combined with lung-on-chip technologies, Arunima Sengupta (University of Bern)
- A predictive multi-organ-chip platform for cancer precision medicine using automated high-content substance testing, Ricky Bayer (TissUse)
- Implementation of AX Barrier-on-chip technology in translational toxicology, Nicole Albrecher (AlveoliX AG)
- A high-throughput 3D spheroid co-culturing platform for investigation of tissue interactions and combined efficacy/safety testing, Olivier Frey, (InSphero AG)
15-17 CET Session 10 - Innovations in Predictive Biology and Toxicology, Session Chair: Barry Hardy (Edelweiss Connect)
- The nephron physiological map and kidney disease ontologies in ONTOX project, Alessio Gamba (University of Liège)
- Efflux mechanism and conformational landscape of P-glycoprotein to better rationalize the prediction of inhibitors involved in drug-drug interactions, Ahmad Elbahnsi (Inserm)
- AI-Driven Insights into Chemical-Protein Dynamics: A Multifaceted Approach, Asmaa Ali Abdelwahab (Edelweiss Connect)
17-19 CET Session 11 - Applications in Aerosol Toxicity and Safety Assessment, Session Chair: Nastassja Lewinski (VCU)
- Biological Engineering to Model Airborne Pathogens and Mitigate their Transmission, Maria King (Texas A&M University)
- Personal sampling of respirable and ultrafine particles in workplaces, Shawn Chen (VCU)
- In Vitro Characterization of a Heated Tobacco Product Collected Using a Novel Method, Lynn McFadden (Toxicology for Enthalpy Specialty Labs)
- Respiratory health evaluation by leveraging lung surfactant fluid, Christie Sayes (Baylor University, Texas)
10 November 2023
13-15 CET Session 12 - In vitro and in vivo Biokinetics – towards an open friendly solution!, Session Chair: Alicia Paini (esqLABs)
- OSPS - PKSim applications in chemical risk assessment, Alicia Paini (esqLABS)
- In vitro distribution mathematical from models in3/ONTOX projects, Susana Proença (Wageningen University)
- Application of in vitro and in vivo modelling for the immune system, Martina Lulini (University of Milan)
- TKPlate: Examples of an open access tool for kinetic modelling in farm animal species, Leonie Lautz (Wageningen Food Safety Research)
15-17 CET Session 13 - OpenTox Career Session: Panel Discussion
17-19 CET Session 14 - Translational Applications in Hepatotoxicity Assessment, Session Chair: Minjun Chen (FDA)
- ToxSTAR: prediction of drug-induced cholestasis, cirrhosis, hepatitis, and steatosis, Hyun Kil Shin (Korean Institute of Toxicology)
- The association of drug interactions for cytochrome P450 (CYP) enzymes and non-CYP enzymes with drug-induced liver injury in humans, AyoOluwa O. Olubamiwa (FDA)
- AI/ML-driven Predictive Modeling of Drug-Induced Liver Injury (DILI) Severity in Small Molecules, Mohan Rao (Neurocrine Biosciences)