Towards intelligent in vitro safety testing with high-content imaging

Presented at the 2018 OpenTox Euro Conference in Athens, Greece. 

Ola Spjuth, Associate Professor, Uppsala University, Sweden

Contemporary in vitro approaches for studying toxicity mechanisms and pathways are in many cases costly and have long iteration cycles because of manual lab operations and disconnected data analysis. This presentation presents our efforts in building a fully automated, robotized cell profiling laboratory with high-content imaging to study cellular mechanisms relevant to toxicity. The instruments are connected to an associated informatics infrastructure to automate data acquisition, preprocessing, and predictive modeling.