30-31 October 2019: Technology Park Basel, Hochbergerstrasse 60C, 4057 Basel, Switzerland
This conference will provide participants an exposure to research and application developments in the emerging area of integrated approaches to testing and assessment (IATAs) supporting goals in risk and safety assessment.
30 October Program
08.00 - Morning Coffee
08.30 - Session 1: Open Science enabling Access to Data Resources, Chair: Barry Hardy (OpenTox Association)
- Thomas Exner (Edelweiss Connect): Towards building harmonized and interoperable e-infrastructures for reproducible new approach toxicology
- Priyanka Banerjee (Charité): Alternative Approaches to the Safety Assessment of Natural Products
- Daniel Burgwinkel (KRM Competence Center, Switzerland): Trust in cloud-based Safety Assessment
10.00 - Panel Discussion
10.30 - Coffee and Networking
11.00 - Session 2: In Vitro Methods, Chair: Tommaso Serchi (LIST)
- Elisa Moschini (LIST): A 3D-tetraculture system at the air-liquid interface as a valuable tool for hazard assessment of respiratory irritants and sensitizers
- Shareen Doak (Swansea University): 3D liver spheroids for acute and long-term engineered nanomaterial in vitro genotoxicity testing
- Stefan Braam (Ncardia): Rethinking translational predictivity using hiPSC-derived models: a retrospective analysis for cardiac liabilities
12.00 - Panel Discussion
12.30 - Lunch
14.00 - Session 3: In Silico Modelling, Chair: Martin Smiesko (University of Basel)
- Martin Smiesko (University of Basel): Large-scale in silico toxicity profiling of compounds contained in printing inks for food packaging materials
- Charleen Don (University of Basel): Cytochrome P450 2D6 as an anti-target for in silico modeling
- Maria Mitvea (INSERM): Integrated Mechanistic and Machine Learning Approach to predict Drug-Drug Interactions of CYP
15.00 Coffee break
- Dr. Jitao David Zhang (F. Hoffmann-La Roche Ltd.): Multiscale modelling of drug mechanism and safety
- Dharmendra K. Yadav (Pharmaceutical Science & Department of Pharmacy, College of Pharmacy, Gachon University) Insight into the molecular dynamic simulations of oxidized skin lipid bilayer and permeability of reactive oxygen species
- Daan Geerke (VU Amsterdam): Site-of-metabolism prediction in OpenRiskNet
16.30 - Panel Discussion
17.00 - Poster Session and Reception
18.00 - Close
31 October Program
08.00 - Registration
08.30 - Session 4: Adverse Outcome Pathways, Chair: Tatyana Doktorova (Edelweiss Connect)
- Saravanakumar Selvaraj (Medical University of Hannover): An adverse outcome pathway for diclofenac induced immune mediated and allergic hepatitis
- Catherine Jane Messner (Fachhochschule Nordwestschweiz): Investigating the link between cholestasis and fibrosis
- Roman Li (National Institute of Biology): Generation of prospective adverse outcome pathways from computable biological networks
- Armin Wolf (InSphero): Pragmatic applications of Adverse Outcome Pathways in Investigative Toxicology in the Deconvolution of DILI mechanisms
09.30 - Panel Discussion
10.00 - Coffee and Networking
10.30 - Session 5: Integrated Testing Methods, Chair: Assia Kovatcheva
- Lucian Farcal (Edelweiss Connect): ACEnano knowledge infrastructure to support data collection, methods optimization and knowledge sharing in the area of physicochemical characterisation of nanomaterials
- Ana Milosevic (EMPA): The national contactpointnano.ch for safe handling of nanomaterials, regulation and knowledge transfer
- Frank Staubli (Nebion): Data integration into GENEVESTIGATOR: overcoming challenges and creating opportunities
11.30 - Panel Discussion
12.00 - Lunch
13.00 - Session 6: Risk Assessment, Chair: Blanca Suarez (Temas)
- Isabel Rodriguez (GAIKER): 3D and explant skin models for determining hazard potential of NMs for Risk Assessment
- Michael Riediker (SCOEH) Occupational risk assessment and novel approaches
- Barbara Rothen-Rutishauser (Université de Fribourg) Predictive 3D epithelial tissue models – opportunities and limitations towards regulatory approval
14.00 - Panel Discussion
14.30 - Coffee and Networking
15.00 - Session 7: 3Rs and Acceptance of New Methods, Chair: Armand Mensen (Swiss 3R Competence Centre)
- Olga Tcheremenskaia (Istituto Superiore di Sanità): Integrated Weight-of-Evidence assessment of genotoxicity: lessons learned from EFSA project on evaluation of applicability of existing in silico models for predicting the genotoxicity of pesticides and their metabolites
- Andreas Natsch (Givaudan; Vernier, Switzerland): Defined Approaches to Testing and Assessment for Skin Sensitization
- Melanie Fischer (EAWAG): Fish cell lines of rainbow trout as alternatives to fish in environmental risk assessment
16.00 - Panel Discussion
16.30 - Close