All Times in CET (e.g.13.30 CET = 7.30 am New York, 12.30 pm London, 5 pm Mumbai, 10.30 pm Tokyo)
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Preliminary Program
Monday 25 November
13-15 CET Session 1 - Data Management, Session Chair: Ugis Sarkans (EMBL-EBI)
- RISK-HUNT3R Knowledge Infrastructure supporting Risk Assessment Workflows, Barry Hardy (Edelweiss Connect)
- Expectations from omics data when testing xenobiotics, Robert Russell (University of Heidelberg)
- Enhancing Risk Assessment Knowledge Exchange: Latest Advances in the RAKIP Initiative, Matthias Filter (BfR)
- Enabling safe and sustainable material design via interoperable data and modelling tools, Thomas Exner (Seven Past Nine)
15-17 CET Session 2 - Knowledge Graphs and Maps, Session Chair: Alessio Gamba (University of Liège)
17-19 CET Session 3 - Toxicity Profiling, Screening and Prediction, Session Chair: Ruili Huang (NIH)
- NIEHS DIVER Platforms: Data Integration and Visualization of In Vitro Developmental Neurotoxicity (DNT) and Zebrafish Developmental Toxicity (DT) Screening Data, Jui-Hua Hsieh (NIEHS)
- Use of in vitro assay system to identify environmental toxicants, Menghang Xia (NCATS)
Tuesday, 26 November
13-15 CET Session 4 - AI Advances in Computational Toxicology, Session Chair: Thomas Hartung (Johns Hopkins and University of Konstanz)
- ToxAIcology – AI will only replace toxicologist, who do not use it!, Thomas Hartung (Johns Hopkins and University of Konstanz)
- AI-facilitated workflows in ONTOX, Marc Teunis (HU University of Applied Sciences Utrecht, Hogeschool Utrecht)
- BioBricks for mining public databases on chemical properties, Tom Luechtefeld (ToxTrack and Insilica)
- Probabilistic Risk Assessment, Alexandra Maertens (Johns Hopkins University)
- Bridging AI and Toxicology: Explainable Methods with TISBE and TIRESIA, Nicola Gambacorta (University of Bari Aldo Moro)
15-17 CET Session 5 - Cardiotoxicity, Session Chair: Svetoslav Slavov (FDA)
17-20 CET Session 6 - Toxicokinetics, Session Chair: Matt Linakis and Harvey Clewell (Ramboll)
- AWESOM: a GNN-based Site-Of-Metabolism Predictor with Aleatoric and Epistemic Uncertainty Estimation, Roxane Jacob (University of Vienna)
- A Tiered Testing Strategy for PBK Modelling: An Investigation of the Effect of Data Reliability and Quality on Model Performance, Hiba Khalidi (Certara)
- A Physiologically-Based Kinetic Model for Inhalation Exposure of Perfluorooctanoic Acid (PFOA) in Rats, Paraskevi Papakyriakopoulou (National Technical University of Athens)
- Next-Generation Risk Assessment (NGRA) Approaches for Systemic Toxicity: Integrating In Silico and In Vitro Methods, Ans Punt (Unilever)
- QIVIVE and reverse dosimetry using TKPlate, Jean Lou Dorne (EFSA)
- Expanding High Throughput IVIVE Methods to Volatile and PFAS Chemistries, John Wambaugh (US EPA)
- Evaluating the Impact of Anatomical and Physiological Variability on Human Equivalent Doses using PBPK Models, Celia Schacht (US EPA)
Wednesday, 27 November
11-13 CET Session 7 - Liver toxicity Session Chair: Marije Niemeijer (University of Leiden)
- Organobodies; A novel way to generate high-throughput 3D multi-cellular liver model, Mostafa Kiamehr (KU Leuven)
- Advanced liver 3D in vitro methods for translational toxicology, (Volker Lauschke, Karolinska Institute)
- Human population variability of toxicodynamics driving adverse responses in hepatocytes, Marije Niemeijer (Leiden University)
13-15 CET Session 8 - Genotoxicity, Session Chair: Marc Audebert (INRA)
- Use of the gammaH2AX/pH3 in vitro genotoxicity method for genotoxicity mode of action determination in the context of chemical risk assessment, Marc Audebert (INRA)
- Implementation of a workflow for an Integrated Testing Strategy for genotoxicity using QSAR-based tools, José Luis Vallés Pardo (ProtoQSAR)
15-17 CET Session 9 - Endocrine Disruption Session Chair: Carolina Horta Andrade (UFG)
- The concern for endocrine disruptors addressed in the EU Regulations, Costanza Rovida (TEAM Mastery)
- Endocrine disruption and neurotoxicity induced by emerging contaminants, Daniel Junqueira Dorta (University of Sao Paulo)
- Advanced Artificial Intelligence Models for the Prediction of Progesterone Endocrine Disruptors, Ester Souza (Federal University of Goias)
17-19 CET Session 10 - AI in Risk Assessment, Session Chair: Ting Li (FDA/NCTR)
- OpenTox AI Perspective, Asmaa Ali (Edelweiss Connect)
- Leveraging LLMs to Curate a Unified Dataset of Drug-Induced Toxicity from FDA Labels, Jake Silberg (Stanford University)
- Deep Generative Learning of Single Cell Gene Expression to predict Dose-Dependent Chemical Perturbations, Sudin Bhattacharya (Michigan State University)
- Considerations for AI driven risk assessments for regulatory applications, Shraddha Thakkar (FDA/CDER)
Thursday, 28 November
13-15 CET Session 11 - New Approach Methods, Session Chair: Yvonne Kohl (Fraunhofer)
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An integrated in vitro and in silico testing strategist to study the effect of four PFAS on the antibody production, Martina Lulini (University of Milan)
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Placental Barrier Permeability Prediction using Mutli-task Learning, Swapnil Chavan (RISE)
15-17 CET Session 12 - Environmental Assessment, Session Chair: Willie Peijnenburg (University of Leiden)
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Integration of safety assessment and LCA within SSbD, Lya Hernandez (RIVM)
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The roles of Environmental Risk Assessment and Life Cycle assessments in SSbD, Jeroen Guinee (University of Leiden)
17-19 CET Session 13 - Advanced In Vitro Models for Kidney Biology and Toxicology Investigations, Session Chair: Paul Jennings (Free University of Amsterdam)
Friday, 29 November
13-15 CET Session 14 - Computational Toxicology Supporting Risk Assessment, Session Chair: Antreas Afantitis (Nova Mechanics)
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In silico prediction of toxicity - let’s use fingerprints, Gerhard Ecker (University of Vienna)
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Retinoic acid receptor (RAR) antagonism modelling with focus on in-house practices for data curation, model validation and reporting, Eva Bay Wedebye (Technical University of Denmark)
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ToxPipe – Chatbots and Retrieval-Augmented Generation on Toxicological Data Streams, Trey Saddler (NIH/NIEHS)
15-17 CET Session 15 - Knowledge-based Investigations in Mechanistic Toxicology, Session Chair: Barry Hardy (Edelweiss Connect)
17-19 CET Session 16 - Environmental Assessment, Session Chair: Asish Mohapatra (Health Canada)
- In silico as a tool for a better use of environmental in vitro toxicity assays, Pierre-Andre Billat (INERIS)
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In silico toxicity predictions using the q-RA and q-RASAR approaches, Kunal Roy (Jadavpur University)
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Conceptual Framework for a Modern Approach to assess Human Health and Ecological Risk from Agrochemicals using Read-across to Reduce Vertebrate Testing, Amber Goetz (Syngenta)