All Times in CET (e.g.13.30 CET = 7.30 am New York, 12.30 pm London, 5 pm Mumbai, 10.30 pm Tokyo)

-----------------------------------------------------------------------------------------------------------------------------------------------

Preliminary Program

Monday 25 November 

13-15 CET Session 1 - Data Management, Session Chair: Ugis Sarkans (EMBL-EBI)

• RISK-HUNT3R Knowledge Infrastructure supporting Risk Assessment Workflows, Barry Hardy (Edelweiss Connect)
• Expectations from omics data when testing xenobiotics, Robert Russell (University of Heidelberg)
• Enhancing Risk Assessment Knowledge Exchange: Latest Advances in the RAKIP Initiative, Matthias Filter (BfR)
• Enabling safe and sustainable material design via interoperable data and modelling tools, Thomas Exner (Seven Past Nine) 

15-17 CET Session 2 - Knowledge Graphs and Maps, Session Chair: Alessio Gamba (University of Liège)

17-19 CET Session 3 - Toxicity Profiling, Screening and Prediction, Session Chair: Ruili Huang (NIH)

• NIEHS DIVER Platforms: Data Integration and Visualization of In Vitro Developmental Neurotoxicity (DNT) and Zebrafish Developmental Toxicity (DT) Screening Data, Jui-Hua Hsieh (NIEHS)
• Use of in vitro assay system to identify environmental toxicants, Menghang Xia (NCATS)

Tuesday, 26 November 

13-15 CET Session 4 - AI Advances in Computational Toxicology, Session Chair: Thomas Hartung (Johns Hopkins and University of Konstanz)

• ToxAIcology – AI will only replace toxicologist, who do not use it!, Thomas Hartung (Johns Hopkins and University of Konstanz)
• AI-facilitated workflows in ONTOX, Marc Teunis (HU University of Applied Sciences Utrecht, Hogeschool Utrecht) 
• BioBricks for mining public databases on chemical properties, Tom Luechtefeld (ToxTrack and Insilica)
• Probabilistic Risk Assessment, Alexandra Maertens (Johns Hopkins University)
• Bridging AI and Toxicology: Explainable Methods with TISBE and TIRESIA, Nicola Gambacorta (University of Bari Aldo Moro)

15-17 CET Session 5 - Cardiotoxicity, Session Chair: Svetoslav Slavov (FDA)

17-20 CET Session 6 - Toxicokinetics, Session Chair: Matt Linakis and Harvey Clewell (Ramboll)

• AWESOM: a GNN-based Site-Of-Metabolism Predictor with Aleatoric and Epistemic Uncertainty Estimation, Roxane Jacob (University of Vienna)
• A Tiered Testing Strategy for PBK Modelling: An Investigation of the Effect of Data Reliability and Quality on Model Performance, Hiba Khalidi (Certara)
• A Physiologically-Based Kinetic Model for Inhalation Exposure of Perfluorooctanoic Acid (PFOA) in Rats, Paraskevi Papakyriakopoulou (National Technical University of Athens) 
• Next-Generation Risk Assessment (NGRA) Approaches for Systemic Toxicity: Integrating In Silico and In Vitro Methods, Ans Punt (Unilever)
• QIVIVE and reverse dosimetry using TKPlate, Jean Lou Dorne (EFSA)
• Expanding High Throughput IVIVE Methods to Volatile and PFAS Chemistries, John Wambaugh (US EPA)
• Evaluating the Impact of Anatomical and Physiological Variability on Human Equivalent Doses using PBPK Models, Celia Schacht (US EPA)

Wednesday, 27 November 

11-13 CET Session 7 - Liver toxicity Session Chair:  Marije Niemeijer (University of Leiden)

• Organobodies; A novel way to generate high-throughput 3D multi-cellular liver model, Mostafa Kiamehr (KU Leuven)
• Advanced liver 3D in vitro methods for translational toxicology, (Volker Lauschke, Karolinska Institute)
• Human population variability of toxicodynamics driving adverse responses in hepatocytes, Marije Niemeijer (Leiden University)

13-15 CET Session 8 - Genotoxicity, Session Chair: Marc Audebert (INRA)

• Use of the gammaH2AX/pH3 in vitro genotoxicity method for genotoxicity mode of action determination in the context of chemical risk assessment, Marc Audebert (INRA)
• Implementation of a workflow for an Integrated Testing Strategy for genotoxicity using QSAR-based tools, José Luis Vallés Pardo (ProtoQSAR)

15-17 CET Session 9 - Endocrine Disruption Session Chair: Carolina Horta Andrade (UFG)

• The concern for endocrine disruptors addressed in the EU Regulations, Costanza Rovida (TEAM Mastery)
• Endocrine disruption and neurotoxicity induced by emerging contaminants, Daniel Junqueira Dorta (University of Sao Paulo)
• Advanced Artificial Intelligence Models for the Prediction of Progesterone Endocrine Disruptors, Ester Souza (Federal University of Goias)

17-19 CET Session 10 - AI in Risk Assessment, Session Chair: Ting Li (FDA/NCTR)

• OpenTox AI Perspective, Asmaa Ali (Edelweiss Connect)
• Leveraging LLMs to Curate a Unified Dataset of Drug-Induced Toxicity from FDA Labels, Jake Silberg (Stanford University)
• Deep Generative Learning of Single Cell Gene Expression to predict Dose-Dependent Chemical Perturbations, Sudin Bhattacharya (Michigan State University)
• Considerations for AI driven risk assessments for regulatory applications, Shraddha Thakkar (FDA/CDER)

Thursday, 28 November 

13-15 CET Session 11 - New Approach Methods, Session Chair: Yvonne Kohl (Fraunhofer)

• An integrated in vitro and in silico testing strategist to study the effect of four PFAS on the antibody production, Martina Lulini (University of Milan)

• Placental Barrier Permeability Prediction using Mutli-task Learning, Swapnil Chavan (RISE)

15-17 CET Session 12 - Environmental Assessment, Session Chair: Willie Peijnenburg (University of Leiden) 

• Toward improving the prediction confidence of in silico approaches to address the decline of wild pollinators and to support environmental risk assessment policy, Olga Tcheremenskaia (ISS)

• Integration of safety assessment and LCA within SSbD, Lya Hernandez (RIVM)

• The roles of Environmental Risk Assessment and Life Cycle assessments in SSbD, Jeroen Guinee (University of Leiden)

17-19 CET Session 13 - Advanced In Vitro Models for Kidney Biology and Toxicology Investigations, Session Chair: Paul Jennings (Free University of Amsterdam)

Friday, 29 November 

13-15 CET Session 14 - Computational Toxicology Supporting Risk Assessment, Session Chair: Antreas Afantitis (Nova Mechanics)

• In silico prediction of toxicity - let’s use fingerprints, Gerhard Ecker (University of Vienna)

• Retinoic acid receptor (RAR) antagonism modelling with focus on in-house practices for data curation, model validation and reporting, Eva Bay Wedebye (Technical University of Denmark)

• ToxPipe – Chatbots and Retrieval-Augmented Generation on Toxicological Data Streams, Trey Saddler (NIH/NIEHS)

15-17 CET Session 15 - Knowledge-based Investigations in Mechanistic Toxicology, Session Chair: Barry Hardy (Edelweiss Connect)

17-19 CET Session 16 - Environmental Assessment, Session Chair: Asish Mohapatra (Health Canada)

• In silico as a tool for a better use of environmental in vitro toxicity assays, Pierre-Andre Billat (INERIS)

• In silico toxicity predictions using the q-RA and q-RASAR approaches, Kunal Roy (Jadavpur University)

• Conceptual Framework for a Modern Approach to assess Human Health and Ecological Risk from Agrochemicals using Read-across to Reduce Vertebrate Testing, Amber Goetz (Syngenta)